Tumour necrosis factor binding ligands

Details Tumour necrosis factor binding ligands Tumour necrosis factor binding ligands

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2064915

The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the TNF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumour and tumour regression activities of the TNF are enhanced; and the cytotoxicity and receptor binding activities of the TNF are unaffected or enhanced on tumour cells. The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding protein. It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragment thereof.

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