A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2273218
A three component therapeutic system comprising (i) a first compound, (ii) a catalytic macromolecule which does not specifically bind to a tumour antigen but which is capable, following administration to the vascular compartment of a mammal, of being taken up by a tumour in the mammal and is capable of converting the first compound into a second compound, and (iii) an inhibitor which, following administration to the said vascular compartment, reduces the level of the said catalytic conversion activity in the vascular compartment.
La présente invention a trait à un système thérapeutique à trois constituants comprenant: (i) un premier composé, (ii) une macromolécule catalytique qui n'est pas spécialement liée à un antigène tumoral mais qui, après son introduction dans la cavité vasculaire d'un mammifère, d'être absorbée par une tumeur se trouvant chez ce mammifère et peut transformer le premier composé en un second composé, et (iii) un inhibiteur qui, après son introduction dans ladite cavité vasculaire, réduit le niveau de ladite activité de conversion catalytique dans la cavité vasculaire.
Enzacta R. & D. Limited
Gowling Lafleur Henderson Llp
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