Two biomarkers for diagnosis and monitoring of...

G - Physics – 06 – F

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G06F 19/24 (2011.01) C40B 30/02 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2710286

The present invention identifies two circulating proteins that have been newly identified as being differentially expressed in atherosclerosis. Circulating levels of these two proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents.

La présente invention concerne l'identification de deux protéines en circulation nouvellement identifiées comme étant exprimées de façon différentielle dans l'athérosclérose. Les taux de circulation de ces deux protéines, notamment sous la forme d'une microplaque de protéine, peuvent distinguer les patients souffrant d'un infarctus du myocarde aigu de ceux qui subissent un angor d'effort stable et de ceux qui ne présentent aucun antécédent d'athérosclérose cardiovasculaire. Ces taux peuvent également prédire des évènements cardiovasculaires, déterminer l'efficacité d'un traitement, le stade d'une pathologie et similaires. À titre d'exemple, ces marqueurs sont utiles en tant que biomarqueurs succédanés d'évènements cliniques nécessaires pour le développement d'agents pharmaceutiques vasculaires spécifiques.

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