Two-component genome flavivirus and uses thereof

Details Two-component genome flavivirus and uses thereof Two-component genome flavivirus and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) C12N 15/40 (2006.01)

Patent

CA 2686398

The present invention discloses a two-component genome flavivirus and a method for propagating such virus. Since the genetic material of this flavivirus is distributed between two genomes, the flavivirus is deficient in replication, incapable of causing disease but capable of inducing an immune response. Nevertheless, the design of the replication deficient flavivirus discussed herein allows propagation of these flaviviruses at industrial level.

La présente invention concerne un flavivirus présentant un génome à deux constituants et une méthode de propagation d'un tel virus. Le matériel génétique de ce flavivirus étant réparti entre deux génomes, le flavivirus est donc non réplicatif, est incapable de provoquer une maladie, mais peut induire une réponse immunitaire. Néanmoins, le flavivirus non réplicatif de l'invention permet la propagation de ces flavivirus à l'échelle industrielle.

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