Two-dimensional sensor having photoconductive layer for...

Details Two-dimensional sensor having photoconductive layer for... Two-dimensional sensor having photoconductive layer for...

G - Physics

01

N

G01N 27/327 (2006.01) C12Q 1/02 (2006.01) G01N 27/30 (2006.01) G01N 33/487 (2006.01)

Patent

CA 2179458

A two-dimensional sensor includes a photoconductive layer whose conductivity increases at a light-irradiated spot, an insulating layer formed on the front surface of the photoconductive layer, an effect electrode formed on the back surface of the photoconductive layer, and a fence as a cell holder attached to the surface of the insulating layer for containing a cell, culture medium and a reference electrode. The sensor is placed in an incubator and a bias voltage is applied between the effect and reference electrodes. When a laser beam irradiates a spot of the back surface of the sensor, a signal is obtained from the effect electrode. This signal corresponds to a potential alteration due to the cell activity substantially at the laser-irradiated spot. The signal is processed in a computer. The beam spot size and location, corresponding to the size and the location of the measurement electrode, can be changed or adjusted easily by focusing or moving the laser beam.

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