Two or more enteric materials to regulate drug release

Details Two or more enteric materials to regulate drug release Two or more enteric materials to regulate drug release

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2514879

Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by having a sustained release profile at lower pH and an accelerated dissolution profile at higher pH.

L'invention concerne des compositions pharmaceutiques, plus particulièrement des formes de dosage oral, contenant deux ou plusieurs matériaux de revêtement entériques, utilisés soit en tant que revêtement soit en tant que forme de dosage de matrice. L'invention concerne également des procédés de fabrication et d'utilisation de ces compositions. Les compositions de l'invention sont caractérisées en ce qu'elles contiennent un profil de libération soutenu à un pH inférieur et un profil de dissolution accélérée à un pH supérieur.

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