Two-phase processing of thermosensitive polymers for use as...

A - Human Necessities – 01 – N

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A01N 43/04 (2006.01) A61L 24/00 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) C07K 1/107 (2006.01) A61K 9/16 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2440844

A two-step system for preparing biomaterials from polymeric precursors is disclosed. The method involves (a) shaping the polymeric precursors by inducing thermal gelation of an aqueous solution of the polymeric precursors and (b) curing the polymeric precursors by cross-linking reactive groups on the polymeric precursors to produce a cured material. The curing reaction involves either a Michael-type addition reaction or a free radical photopolymerization reaction in order to cross-link the polymeric materials. The biomaterials produced by this method have a variety of biomedical uses, including drug delivery, microencapsulation, and implantation.

L'invention concerne un procédé en deux étapes pour préparer des biomatériaux à partir de précurseurs polymères. Ce procédé consiste à (a) façonner les précurseurs polymères par gélification thermique d'une solution aqueuse desdits précurseurs polymères, et à (b) faire réticuler ces précurseurs polymères au moyen de groupes réactifs de durcissement, pour obtenir un matériau réticulé. La réaction de réticulation fait intervenir soit une réaction d'addition de type Michael, soit une réaction de photopolymérisation radicale libre pour durcir les matériaux polymères. Les biomatériaux ainsi produits présentent une variété d'utilisations dans le domaine biomédical, comprenant l'administration de médicaments, la microencapsulation et l'implantation.

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