Two stage enrichment of cell-free fetal dna in maternal plasma

Details Two stage enrichment of cell-free fetal dna in maternal plasma Two stage enrichment of cell-free fetal dna in maternal plasma

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2713545

The present invention provides methods for enriching fetal nucleic acid in a biological sample from a maternal host. Also provided are methods for detecting the presence or absence of markers in fetal, tu-mor, or neoplastic nucleic acid. The methods can include treating the bio-logical sample with DNase and, optionally, performing whole genome amplification on the treated samples. The biological sample can be, for example, a blood sample.

La présente invention concerne des procédés pour enrichir un acide nucléique ftal dans un échantillon biologique provenant d'un hôte maternel. L'invention concerne également des procédés pour détecter la présence ou l'absence de marqueurs dans un acide nucléique ftal, tumoral ou néoplasique. Les procédés peuvent comprendre le traitement de l'échantillon biologique avec de la désoxyribonucléase (DN-ase) et, facultativement, l'exécution d'une amplification complète de génome sur les échantillons traités. L'échantillon biologique peut être, par exemple, un échantillon de sang.

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