Two step cluster deletion and humanisation

Details Two step cluster deletion and humanisation Two step cluster deletion and humanisation

C - Chemistry, Metallurgy

12

N

C12N 15/90 (2006.01) A01K 67/027 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2699547

This invention relates to a method for humanising a mouse. In particular, the invention relates to a method for replacing a cluster of mouse genes with single or multiple genes from the corresponding human cluster using a combination of homologous recombination and site-specific recombination.

La présente invention concerne un procédé d'humanisation d'une souris. En particulier, l'invention concerne un procédé visant à remplacer un groupe de gènes de souris par un ou plusieurs gènes du groupe de gènes humains correspondant en associant une recombinaison homologue et une recombinaison spécifique du site.

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