C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/22 (2006.01) A61K 31/353 (2006.01) A61P 9/10 (2006.01) C07D 311/32 (2006.01)
Patent
CA 2743618
Two crystalline forms of pinocembrin of formula (I): .alpha. and .beta., their preparation and their use for manufacture of pharmaceutical compositions. There exists difference between them in bioavailability. They are used for treating and preventing cerebral ischemic diseases by protective action of neurovascular unit, and enhancing blood drug level in vivo.
La présente invention concerne deux formes cristallines de pinocembrine de formule (I) : a et ß, leur préparation et leur utilisation pour la fabrication de compositions pharmaceutiques. Il existe une différence entre celles-ci en terme de biodisponibilité. Elles sont utilisées pour traiter et prévenir des maladies ischémiques cérébrales par action protectrice des cellules neurovasculaires, et augmentation du taux sanguin de médicament in vivo.
Chang Ying
Du Guanhua
Gao Mei
Lv Yang
Tong Yuanfeng
Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co. Ltd.
Institute Of Materia Medica Chinese Academy Of Medical Sciences
Oyen Wiggs Green & Mutala Llp
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