Type 2 cytokine receptor and nucleic acids encoding same

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2434652

The present invention provides novel isolated CRF2-12 polynucleotides and polypeptides encoded by the CRF2-12 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-12 polypeptide or any derivative (including fusion derivative), variant, mutant of the CRF2-12 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-12 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

La présente invention concerne de nouveaux polynucléotides et polypeptides de la famille des récepteurs de cytokine de type 2-12 isolés, codés par les polynucléotides de la famille des récepteurs de cytokine de type 2-12. L'invention concerne également les anticorps qui se fixent de manière immunospécifique à un polypeptide de la famille des récepteurs de cytokine ou à n'importe quel dérivé (y compris un dérivé de fusion), allèle, mutant ou fragment du polypeptide, du polynucléotide ou de l'anticorps de la famille des récepteurs de cytokine de type 2-12. L'invention concerne enfin des méthodes selon lesquelles le polypeptide, le polynucléotide ou l'anticorps de la famille des récepteurs de cytokine de type 2-12 sont utilisés dans la détection et le traitement d'une large gamme d'états pathologiques, ainsi qu'à d'autres fins.

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