Type ii interferon and agents thereof

Details Type ii interferon and agents thereof Type ii interferon and agents thereof

C - Chemistry, Metallurgy

07

K

167/103.1

C07K 14/57 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1135622

ABSTRACT OF THE DISCLOSURE The present invention relates to processes which are easily applicable for industrial production of Type II interferon and Type II interferon-containing agents. Particularly, the present processes are based on the invention that a large amount of high-titred Type II interferon is easily obtainable by transplanting established human cells in other warm-blooded animal body or inoculating the cells in a culture medium charged in a filter-membrane-interposed diffusion chamber which is designed and fitted in or to the animal body so that the cells can grow on its nutrient body fluid, multiplying the transplanted or inoculated cells in the warm-blooded animal body or the diffusion chamber utilizing the body fluid, then exposing the multiplied cells to the action of a Type II interferon inducer in vivo or in vitro to induce Type II interferon, and purifying and separating the induced Type II interferon, and are also based on the invention that the agents containing Type II interferon obtained by the method disclosed herein are effective and superior for treating and preventing Type II interferon-sensitive diseases.

343891

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