Type iii secretion system antigens from bordetella pertussis

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/10 (2006.01) C07K 14/235 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2356764

This invention relates to a general method for detecting pathogenic strains of bacteria which harbour a type III secretion system. More particularly, this invention relates to the methods as applied to the pathogen <i>Bordetella pertussis</i>. Furthermore, the invention relates to newly identified polynucleotides within these regions, virulent polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly the polynucleotides and polypeptides of the present invention relate to the virulent effector proteins associated with the type III secretion system of <i>Bordetella pertussis</i>, which are particularly suitable for vaccine purposes.

La présente invention concerne un procédé permettant de détecter des souches de bactéries pathogènes qui contiennent un système de sécrétion de type III. Plus particulièrement, la présente invention concerne le procédé appliqué au Bordetella pertussis pathogène. En outre, l'invention concerne des polynucléotides qui viennent d'être identifiés dans ces régions, des polypeptides virulents codés par ces derniers, et l'utilisation de ces polynucléotides et polypeptides, et leur production. Plus particulièrement, les polynucléotides et les polypeptides selon l'invention concernent les protéines effectrices virulentes associées au système de sécrétion de type III de Bordetella pertussis, qui sont particulièrement appropriées pour être utilisées dans les vaccins.

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