Tyrosine derivatives as ppar-gamma-modulators

Details Tyrosine derivatives as ppar-gamma-modulators Tyrosine derivatives as ppar-gamma-modulators

C - Chemistry, Metallurgy

07

C

C07C 233/88 (2006.01) A61K 31/198 (2006.01) A61K 31/341 (2006.01) A61K 31/4406 (2006.01) A61K 31/47 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 229/36 (2006.01) C07C 233/20 (2006.01) C07C 233/69 (2006.01) C07D 213/56 (2006.01) C07D 215/14 (2006.01) C07D 307/54 (2006.01)

Patent

CA 2574021

Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents -(CH2)s-N(COR3)-A-J- T or -(CH2)S-N(R4)-B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPAR.gamma. modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.

L'invention concerne des composés de formule générale (I), ainsi que des sels et des solvates de ces composés. Dans ladite formule (I) : R1 représente le radical 2-benzoylphénylamino ; R2 désigne -(CH2)s-N(COR3)-A-J-T ou -(CH2)<SB>S</SB>-N(R4)-B-J-T, et ; s, R3, R4, A, B, J et T sont tels que définis dans la description. Ces composés sont des modulateurs des récepteurs PPAR.gamma. et peuvent, par conséquent, être utilisés pour traiter ou prévenir un état ou une maladie dont la médiation est assurée par lesdits récepteurs.

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