Tyrosine kinase inhibitor compositions and methods for...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/28 (2006.01)

Patent

CA 2600375

A new ErbB-based ligand binding molecule is disclosed along with its method of preparation and use. The binding molecule is a protein expressed from a recombinant DNA molecule. The protein contains an ErbB extracellular domain that binds to activating ligands. These binding elements act as traps to bind and sequester circulating ligands, thus making them unavailable for binding to cellular ErbB receptors.

L'invention concerne une molécule de liaison de ligand à base de ErbB, ainsi qu'un procédé de préparation et d'utilisation de celle-ci. La molécule de liaison est une protéine exprimée à partir d'une molécule d'ADN recombinante. La protéine renferme un domaine extracellulaire ErbB se liant à des ligands activateurs. Ces éléments de liaison agissent comme piège aux fins de liaison et de séquestre de ligands circulant, les rendant ainsi non disponibles pour la liaison à des récepteurs cellulaires ErbB.

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