C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/22 (2006.01) A61K 31/439 (2006.01) A61P 35/00 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2480879
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non- receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
La présente invention concerne des composés capables d'inhiber, de moduler et/ou de réguler la transduction de signal des tyrosines kinases de type récepteur et de type non récepteur. Les composés décrits dans cette invention présentent une structure de noyau qui comprend une fraction benzazocine. La présente invention concerne également des sels pharmaceutiquement acceptables, des hydrates et des stéréo-isomères de ces composés.
Dinsmore Christopher J.
Graham Samuel L.
Kim Annette
Nguyen Diem N.
Stump Craig A.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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