Tyrosine kinase inhibitors

Details Tyrosine kinase inhibitors Tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2624676

The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des dérivés d'imidazo[1,2-a]pyrimidine, qui sont utiles pour traiter des maladies hyperplasiques, pour traiter des troubles associés à l'activité du récepteur MET, et pour inhiber le récepteur tyrosine kinase MET. L'invention concerne également des compositions comprenant ces composés, ainsi que des méthodes dans lesquelles ces compositions sont utilisées pour traiter le cancer chez les mammifères.

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