Tyrosine kinase inhibitors

Details Tyrosine kinase inhibitors Tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 221/16 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2656578

The present invention relates to 5H-benzo[4,5]cyclohepta[ 1,2-b]pyridine derivatives of formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des dérivés de la 5H-benzo[4,5]cyclohepta[1,2-b]pyridine utilisables pour le traitement des maladies de prolifération cellulaire, pour le traitement des troubles associés à une activité MET et pour l'inhibition du récepteur à activité tyrosine kinase, MET. L'invention concerne également des compositions qui comprennent ces composés et des procédés qui les utilisent pour traiter un cancer chez des mammifères.

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