Tyrosine kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/08 (2006.01) A61K 31/4995 (2006.01)

Patent

CA 2480758

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non- receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

L'invention concerne des composés permettant d'inhiber, de moduler et/ou de réguler la transduction de signaux à la fois de tyrosine kinases de type récepteur et de type non récepteur. Lesdits composés comprennent une structure de noyau renfermant une fraction de benzazocine. L'invention concerne également des sels pharmaceutiquement acceptables, des hydrates et des stéréoisomères de ces composés.

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