Tyrosine kinase inhibitors

Details Tyrosine kinase inhibitors Tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2532443

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non- receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

L'invention concerne des composés aptes à inhiber, à moduler et/ou à réguler la transduction de signaux de tyrosine kinases, à la fois de type récepteur et de type non-récepteur. Les composés de l'invention présentent une structure centrale comprenant une fraction pyrrole substitué. Ladite invention concerne également les sels pharmaceutiquement acceptables, des hydrates et des stéréoisomères de ces composés.

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