Tyrosine kinase inhibitors

Details Tyrosine kinase inhibitors Tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/333 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2532400

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non- receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a substituted pyrrole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

L'invention concerne des composés capables d'inhiber, moduler et/ou réguler la transduction de signaux des tyrosine kinases de type récepteur et non-récepteur. Les composés selon l'invention possèdent une structure de noyau renfermant une fraction de pyrolle substitué. L'invention concerne enfin des sels, des hydrates et des stéréoisomères acceptables sur le plan pharmaceutique de ces composés.

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