C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A61K 38/45 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2473682
The present invention relates to novel proteins that inhibit the activity of tyrosine kinases. In particular, the invention provides a tyrosine kinase inhibitor protein consisting of the cap region of a c-Abl protein. The invention also relates to the use of tyrosine kinase inhibitor proteins in the treatment and diagnosis of diseases, in particular cancers, in humans.
la présente invention concerne des protéines qui inhibent l'activité des tyrosine kinases, et en particulier une protéine inhibitrice de la tyrosine kinase composée de la région de chapeau d'une protéine a c-Abl. Cette invention porte également sur l'utilisation de protéines inhibitrices de la tyrosine kinase pour le traitement et le diagnostic de maladies chez l'homme, particulièrement de cancers.
Dorey Karel
Pluk Wilhelmina
Superti-Furga Giulio
European Molecular Biology Laboratory
Kirby Eades Gale Baker
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