C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/404 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2493575
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non- receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises an indole-sulfonamide moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
L'invention concerne des composés capables d'inhiber, de moduler et/ou de réguler la transduction des signaux de tyrosine kinases du type aussi bien récepteur que non récepteur. Les composés selon l'invention possèdent une structure centrale qui comprend une fraction indole-sulfonamide. L'invention concerne également des sels pharmaceutiquement acceptables, des hydrates et des stéréoisomères desdits composés.
Bergman Jeffrey M.
Beshore Douglas C.
Dinsmore Christopher J.
Lindsley Craig W.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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