Tyrosine kinase inhibitors

Details Tyrosine kinase inhibitors Tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2606017

The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des dérivés d'imidazo[1,2-a]pyrimidine convenant pour le traitement de maladies dégénératives cellulaires, de troubles associés à l'activité de MET ainsi que pour inhiber le MET de la tyrosine kinase. L'invention concerne également des compositions qui renferment ces composés ainsi que des méthodes d'utilisation de ces compositions pour le traitement du cancer chez les mammifères.

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