Tyrosine kinase inhibitors containing a zinc binding moiety

Details Tyrosine kinase inhibitors containing a zinc binding moiety Tyrosine kinase inhibitors containing a zinc binding moiety

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/506 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2662580

The present invention relates to tyrosine kinase inhibitors that contain a zinc-binding moiety and their use in the treatment of tyrosine related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

L'invention concerne des inhibiteurs de tyrosine kinase qui contiennent un groupe caractéristique de liaison au zinc, et leur utilisation dans le traitement de troubles et de maladies liées à la tyrosine, notamment le cancer. Ces dérivés peuvent, en outre, agir en tant qu'inhibiteurs HDAC.

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