C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/20 (2006.01) C12P 21/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2277983
This invention concerns new PST-PIP polypeptides which an; bound by and dephosphorylated by the PEST family of protein tyrosine phosphatases. The invention specifically concerns native murine PSTPIP polypeptides and their homologues in other mammals, and their functional derivatives. The invention further relates to nucleic acids encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Methods for inducing the polymerization of actin monomers in eukaryotic cells and assays for identifying antagonists and agonists of the PSTP1P polypeptides of the present invention are also provided.
L'invention concerne de nouveaux polypeptides de type PSTPIP, qui se lient à la famille PEST des protéines tyrosine phosphatases et sont déphosphorylées par ladite famille. L'invention concerne spécifiquement des polypeptides murins naturels de type PSTPIP et leurs homologues chez d'autres mammifères, ainsi que leurs dérivés fonctionnels. L'invention concerne aussi des acides nucléiques codant ces protéines, des vecteurs contenant ces acides nucléiques et capables de les exprimer, et des cellules hôtes recombinées transformées par lesdits acides nucléiques. On décrit également des procédés induisant la polymérisation des monomères d'actine dans les cellules eucaryotes et des analyses permettant d'identifier les antagonistes et les agonistes des polypeptides de type PSTPIP de la présente invention.
Dowbenko Donald J.
Lasky Laurence A.
Dennison Associates
Genentech Inc.
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