C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A61K 39/395 (2006.01) C12N 5/20 (2006.01) C12N 9/00 (2006.01) C12N 15/67 (2006.01) C12P 21/08 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2125761
Abstract A method for isolating and purifying novel species of E2 ubiquitin- carrier protein, designated E2-F1, is disclosed. A method for preparing enzymatically active fragments of E2-F1 enzyme is also disclosed. The use of purified E2-F1 to produce antibodies is also disclosed. The use of such E2- F1-specific antibodies to detect the presence of E2-F1 in a biological sample, and to inhibit protein degradation are also disclosed. Recombinant DNA molecules which code for E2-F1, and recombinant hosts and vectors which contain E2-F1 coding sequences are also disclosed. The use of such recombinant hosts and vectors to produce E2-F1 protein is also disclosed. The use of purified E2-F1 to identify and to isolate E3 enzyme is also disclosed. Methods for screening substances for the ability to inhibit E2-F1 enzyme activity are also disclosed.
Blumenfeld Nava
Ciechanover Aaron J.
Gonen Hedva
Gowling Lafleur Henderson Llp
Rappaport Family Institute For Research In The Medical Sciences
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