C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/42 (2006.01) A61K 31/426 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2589830
This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors, particularly ubiquitin ligase inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved, such as signal transduction pathways. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound or pharmaceutical composition according to the invention. Particularly, the compounds and pharmaceutical compositions are useful to inhibit the ubiquitin ligase activity of MDM2.
La présente invention décrit des composés et des compositions pharmaceutiques utiles en tant qu'inhibiteurs d'agents associés à l'ubiquitine, en particulier des inhibiteurs d'ubiquitine-ligases. Les composés et les compositions pharmaceutiques de l'invention sont utiles en tant qu'inhibiteurs des voies biochimiques d'organismes dans lesquels l'ubiquitinylation est impliquée, telles que les voies de transduction de signaux. L'invention concerne également l'utilisation des composés et des compositions pharmaceutiques de l'invention pour le traitement d'affections qui nécessitent l'inhibition de l'ubiquitinylation. En outre, l'invention concerne des procédés d'inhibition de l'ubiquitinylation dans une cellule, comprenant l'étape de mise en contact d'une cellule dans laquelle l'inhibition de l'ubiquitinylation est souhaitée avec un composé ou une composition pharmaceutique selon l'invention. En particulier, les composés et les compositions pharmaceutiques sont utiles pour inhiber l'activité ubiquitine-ligase de MDM2.
Gururaja Tarikere
Huang Jianing
Issakani Sarkiz D.
Kinoshita Taisei
Ramesh Usha
Mbm Intellectual Property Law Llp
Rigel Pharmaceuticals Inc.
LandOfFree
Ubiquitin ligase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ubiquitin ligase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ubiquitin ligase inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1674840