Ubiquitin-specific proteases

Details Ubiquitin-specific proteases Ubiquitin-specific proteases

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C12N 1/21 (2006.01) C12N 9/60 (2006.01) C12N 15/62 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2123107

The disclosure relates to a generic class of ubiquitin-specific proteases which specifically cleave at the C-terminus of the ubiquitin moiety in a ubiquitin fusion protein irrespective of the size of the ubiquitin fusion protein. More specifically, the disclosure relates to ubiquitin-specific proteases of this class which have been isolated from a cell. The disclosure also relates to isolated DNA sequences encoding the proteases of this class.

Une invention a trait à une classe générique de protéases spécifiques de l'ubiquitine dont le clivage se fait au niveau du C terminal de la fraction d'ubiquitine appartenant à une protéine de fusion à base d'ubiquitine, abstraction faite de la taille de cette protéine de fusion. L'invention porte particulièrement sur des protéases spécifiques de l'ubiquitine qui appartiennent à cette classe et ont été isolées dans une cellule. Elle porte aussi sur des séquences isolées dans l'ADN et codant pour les protéases de cette classe.

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