Ucp3 genes

Details Ucp3 genes Ucp3 genes

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303003

The invention provides methods and compositions relating to a novel family of genes, mUCP3s, involved in metabolic regulation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed mUCP3 encoding nucleic acids or purified from mammalian cells. The invention provides isolated mUCP3 hybridization probes, knock-out/in constructs and primers capable of specifically hybridizing with the disclosed mUCP3 genes, mUCP3-specific binding agents such as specific antibodies, animals and cells modified with the subject mUCP3 nucleic acids, and methods of making and using the subject compositions in the biopharmaceutical industry.

L'invention concerne des méthodes et des compositions relatives à une nouvelle famille de gènes, les mUCP3, impliqués dans la régulation métabolique. Les polypeptides peuvent être produits de manière recombinée à partir de cellules hôtes transformées tirées d'acides nucléiques codant les mUCP3 décrits ou purifiés à partir de cellules mammifères. L'invention concerne des sondes isolées d'hybridation de mUCP3, des constructions inactivées/activées et des amorces capables de s'hybrider spécifiquement aux gènes mUPC3 décrits, et des agents de liaison spécifiques au mUCP3 tels que des anticorps spécifiques, des animaux et des cellules modifiées par les acides nucléiques de mUCP3 de l'invention, et des méthodes de production et d'utilisation des compositions de l'invention dans l'industrie biopharmaceutique.

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