Ucp4

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2344467

The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ("UCPs") and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

L'invention porte sur de nouveaux polypeptides présentant une homologie avec certaines protéines humaines brûleuses de graisses excédentaires (UCP) et certaines molécules d'acide nucléique codant pour lesdits polypeptides. L'invention porte également sur des vecteurs et cellules hôtes comportant ces séquences d'acide nucléique, sur des molécules de polypeptide chimériques résultant de la fusion des polypeptides de la présente invention avec des séquences de polypeptides hétérogènes, sur des d'anticorps se fixant aux polypeptides de la présente invention, et sur des procédés de d'obtention des polypeptides de la présente invention.

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