C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 30/04 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) C40B 50/06 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2586028
The present invention relates to a method for identification and isolation of binding molecules having a selective affinity for a ligand. More specifically, this invention provides a process for the ultra high throughput screening of binding molecules from expression libraries containing billions of independent clones without the biases and limitations of other high throughput screening methods such as panning. Additionally, the present invention provides a method for the production of expression libraries essentially free of clones encoding non-functional molecules.
L'invention porte sur un procédé d'identification et d'isolement de molécules de liaison présentant une affinité sélective avec un ligand. Plus précisément, cette invention se rapporte à un procédé de criblage à capacité ultra élevée de molécules de liaison à partir de bibliothèques d'expression contenant des milliards de clones indépendants sans les écarts et les limites des autres procédés de criblage à capacité élevée tels que le lavage à la batée. De plus, l'invention concerne un procédé de fabrication de bibliothèque ne contenant pratiquement pas de clones codant des molécules non fonctionnelles.
Gao Changshou
Wu Herren
Medimmune Inc.
Smart & Biggar
LandOfFree
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