Ultra pure epa and polar lipids produced in largely...

Details Ultra pure epa and polar lipids produced in largely... Ultra pure epa and polar lipids produced in largely...

C - Chemistry, Metallurgy

12

P

C12P 1/00 (2006.01) A61K 31/20 (2006.01) C12P 7/64 (2006.01)

Patent

CA 2656311

Eicosapentaenoic acid (EPA) compositions and EPA-rich polar lipids for prophylactic or therapeutic applications are described. Production from certain cultured micro-organisms (like Nitzschia laevis) promotes synthesis of EPA, including polar lipids including EPA. The EPA-rich polar lipids themselves may be used as polar compounds. EPA can be selectively hydrolysed from particular positions in isolated polar lipids by lipase activity, then optionaly further purified. The process bypasses reliance on diminishing fish stocks and on physico-chemical processes that may not adequately separate desirable n-3 HUFAs from unwanted products like DHA also found in fish oil and cultured organisms.

La présente invention concerne des compositions d'acide eicosapentanoïque (EPA), ainsi que des lipides polaires riches en EPA, destinés à des applications prophylactiques ou thérapeutiques. La production au départ de certains micro-organismes cultivés (tels que Nitzschia laevis) favorise la synthèse d'EPA, incluant des lipides polaires renfermant de l'EPA. Les lipides polaires riches en EPA peuvent être eux-mêmes utilisés en tant que composés polaires. L'EPA peut être sélectivement hydrolysé par l'activité de la lipase au niveau de positions particulières dans les lipides polaires isolés, puis être éventuellement davantage purifié. Le procédé élimine le besoin de réduire les populations de poissons et de recourir à des procédés physico-chimiques susceptibles de ne pas séparer de manière adéquate les acides gras polyinsaturés oméga 3 (n-3 HUFA) souhaitables de produits indésirables, tels que l'acide docosahexaénoïque (DHA) également présent dans l'huile de poisson et certains organismes cultivés.

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