Ultra-violet filtration with certain aminosalicylic acid esters

Details Ultra-violet filtration with certain aminosalicylic acid esters Ultra-violet filtration with certain aminosalicylic acid esters

B - Operations, Transporting

01

J

260/474.1

B01J 25/02 (2006.01) A61K 31/60 (2006.01) B01J 23/06 (2006.01)

Patent

CA 1113486

ABSTRACT OF THE DISCLOSURE Alkyl esters of aminosalicylic acid, said alkyl group having from 1 to 18 carbon atoms in chain length; alkenyl esters of aminosalicylic acid, said alkenyl group selected from the group consisting of vinyl, allyl, undecenyl, oleyl and linolenyl groups, and cyclic esters of aminosalicylic acid, said cyclic group being the cyclohexyl, phenyl and menthyl groups, having ultra-violet screening properties to absorb light rays within the wave-length range of 2950 A. to 3200 A. while transmitting the light rays beyond the 3200 A. range to permit the desirable tanning of the skin without solar burn. The respective esters of aminosalicylic acid are prepared by the reduction of the appropriate nitro-salicylic acid ester with Raney nickel an hydrogen in the presence of ethyl acetate. The respective esters are obtained as oils or solid crystalline substances and are soluble in alcohols, chloroform, acetone and benzene but insoluble in water. The ultra-violet absorption spectra for the respective compounds arc described. Compositions com- prising the above compounds together with the method for their preparation and the method for the use to achieve an ultra- violet filtering action on the skin of humans and animals are described.

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