Ultraconserved regions encoding ncrnas

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/113 (2010.01) G06F 19/10 (2011.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2695514

Described herein are methods for differentiate human cancers comprising using one or more transcribed ultracon-served regions(T-UCR) expression profiles where the association between the genomic location of UCRs and the analyzed can-cer-related genomic elements is highly statistically significant and comparable to that reported for miRNAs.

La présente invention a pour objet des procédés de différenciation des cancers humains comprenant l'utilisation d'un ou plusieurs profils d'expression de régions ultra-conservées transcrites (T-UCR). L'association entre la localisation génomique des UCR et les éléments génomiques liés au cancer analysé est hautement statistiquement significative et comparable à celle rapportée pour les miARN.

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