Ultrapurification of factor viii

Details Ultrapurification of factor viii Ultrapurification of factor viii

A - Human Necessities

61

K

195/1.112

A61K 35/16 (2006.01) C07K 14/755 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1251152

ABSTRACT OF THE DISCLOSURE A method of preparing high purity procoagulant protein comprising the steps of (a) adsorbing a VIII:C/VIII:RP complex from a plasma or commercial concentrate source of factor VIII onto agarose beads bound to a monoclonal antibody specific to VIII:RP, (b) eluting VIII:C with a salt solution, (c) adsorbing the eluted VIII:C on an animohexyl agarose column and eluting the VIII:C with a salt solution.

498216

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