G - Physics – 01 – N
Patent
G - Physics
01
N
349/36, 349/37
G01N 33/49 (2006.01) G01N 27/00 (2006.01) G01N 29/00 (2006.01) G01N 33/86 (2006.01)
Patent
CA 1230667
Abstract of the Disclosure An ultrasonic coagulation monitor for measurement of prothrombin times and related coagulation times includes at least one piezo- electric crystal operated at a fixed frequency near its resonant frequency. A sample of material to be analyzed is placed in acoustic communication with the crystal. The voltage across the crystal is monitored in order to detect a voltage change, preferably a drop, that occurs upon coagulation of the sample. A timer is included that is turned off at a pre- determined voltage drop corresponding to a particular stage of coagulation desired to be timed. In an alternative embodiment of the invention a second crystal is included and is mounted a predetermined distance from the first crystal to define a cavity therebetween. One crystal is driven by the frequency oscillator circuit and the material the coagulation of which is to be measured is placed in the cavity. A voltage sensing device senses the voltage across the second crystal and controls a timer as in the first embodiment. A method of moni- toring prothrombin times and related coagula- tion times is also described. The method in- cludes placing coagulating material in sound absorbing relationship with at least one piezo- electric crystal, driving that crystal at a fixed frequency using a fixed frequency oscil- lator circuit, measuring the voltage in the circuit and determining the amount of time required for the voltage to reach a predeter- mined voltage level.
485104
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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