A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/22 (2006.01) A61K 9/19 (2006.01) A61K 49/18 (2006.01)
Patent
CA 2512454
Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.
La présente invention concerne un procédé permettant d'élaborer une matrice lyophilisée et, après sa reconstitution, un agent de contraste injectable correspondant comprenant une suspension aqueuse liquide de microbulles remplies de gaz stabilisées essentiellement au moyen d'un phospholipide. Le procédé consiste à obtenir d'abord une émulsion à partir d'un milieu aqueux, d'un phospholipide et d'un solvant organique non miscible avec l'eau. L'émulsion est alors lyophilisée puis reconstituée donnant une suspension aqueuse de microbulles remplies de gaz. Le procédé permet l'obtention de suspensions comprenant des microbulles d'un diamètre relativement petit et à distribution étroite des calibres.
Bussat Philippe
Guillot Christian
Schneider Michel
Yan Feng
Bracco Research Sa
Bracco Suisse S.a.
Dimock Stratton Llp
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