A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/25 (2006.01) A61P 9/00 (2006.01) A61P 17/00 (2006.01)
Patent
CA 2723270
The present invention relates to a method for treating a cardiovascular disease, for increasing the number of circulating angiogenic cells (CAC) and/or improving the function of CAC and a method for improving vascular remodeling and/or neovascularisation. The method comprises administering to the subject a therapeutically effective amount of unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1; and to pharmaceutical compositions comprising unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1.
La présente invention porte sur un procédé pour traiter une maladie cardiovasculaire, pour augmenter le nombre de cellules angiogéniques circulantes (CAC) et/ou pour améliorer la fonction des CAC et sur un procédé pour améliorer le remodelage vasculaire et/ou une néo-vascularisation. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace de ghréline non acylée ou un polypeptide renfermant la séquence d'acides aminés établie dans SEQ ID NO: 1 ou un fragment ou analogue associé présentant l'activité biologique de SEQ ID NO: 1 ; et sur des compositions pharmaceutiques renfermant de la ghréline non acylée ou un polypeptide renfermant la séquence d'acides aminés établie dans SEQ ID NO: 1 ou un fragment ou analogue associé présentant l'activité biologique de SEQ ID NO: 1.
Brizzi Maria Felice
Ghigo Ezio
Muccioli Giampiero
Alize Pharma Sas
Smart & Biggar
LandOfFree
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