Unacylated ghrelin as therapeutic agent in the treatment of...

Details Unacylated ghrelin as therapeutic agent in the treatment of... Unacylated ghrelin as therapeutic agent in the treatment of...

A - Human Necessities

61

K

A61K 38/25 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2686803

An isolated polypeptide comprising any amino acid fragment of unacylated ghrelin or any analog thereof, wherein the polypeptide has an activity selected from the group consisting of a) decreasing blood glucose levels; b) increasing insulin secretion an/or sensitivity; c) binding to insulin-secreting cells; and d) promoting survival of insulin-secreting cells. As well as the use of the polypeptide in the treatment of a disorder associated with impaired glucose metabolism.

L'invention concerne un polypeptide isolé comprenant tout fragment d'acide aminé de ghréline non acétylée ou de tout analogue de celui-ci. Le polypeptide possède une activité choisie dans le groupe consistant en a) la diminution des taux de glucose dans le sang; b) l'augmentation de la sécrétion d'insuline et/ou de la sensibilité à l'insuline; c) la liaison à des cellules sécrétant l'insuline; et d) le fait de favoriser la survie de cellules sécrétant l'insuline. L'invention concerne également l'utilisation du polypeptide dans le traitement d'un trouble associé à un métabolisme du glucose défectueux.

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