Uncharged morpholino-based polymers having...

Details Uncharged morpholino-based polymers having... Uncharged morpholino-based polymers having...

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) C07H 21/00 (2006.01) C08G 79/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2069869

A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, phosphorous-containing chiral lin- kages, one to three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.

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