Uncoated tablets and method of producing the same

Details Uncoated tablets and method of producing the same Uncoated tablets and method of producing the same

A - Human Necessities

61

K

A61K 9/20 (2006.01) A01N 25/34 (2006.01) B30B 13/00 (2006.01) C05G 5/00 (2006.01)

Patent

CA 2115308

A compression-moldable composition comprising an active ingredient, an excipient and an oily or fatty substance having a lower melting point of about 20 to 90°C is compression-molded into uncoated tablets without coating to improve the abrasion resistance. The oily or fatty substance includes a higher fatty acid or a salt thereof, a wax, a fatty acid ester, a hardened oil, a polyalkylene oxide, etc., and the amount thereof is about 0.01 to 10% by weight. The composition may comprise (1) a granulated powder containing the active ingredient and the excipient, and the powdery or granular oily or fatty substance having a lower melting point, or (2) a granulated powder containing the active ingredient, the excipient and said oily or fatty substance. Compression-molding of the composition improves the abrasion resistance of the tablet and significantly inhibits the development of powder by wearing or abrasion even when the oily or fatty substance is used in a small amount of about 0.1 to 0.5% by weight.

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