Uncoupling protein homologue: ucp 3

Details Uncoupling protein homologue: ucp 3 Uncoupling protein homologue: ucp 3

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2288901

The present invention relates to the cloned genes which code for uncoupling proteins controlling thermogenesis in human skeletal muscle and heart. A further aspect of the present invention relates to the use of the said genes for correcting dysfunctions of thermogenesis in human skeletal muscle and heart. The present invention makes it possible to exploit novel therapeutic (or preventive) methods for disorders such as obesity or cachexia. As a result of the identification and isolation of the genes coding for UCP3L and UCP3S, it is, in effect, possible to develop medicaments which act on the basis of a correction, by gene therapy or by antisense oligonucleotides relating to the sequence of the gene in question or to one of its fragments, of a lack or an excess of UCP3.

La présente invention concerne des gènes clonés codant des protéines de découplage qui commandent une thermogenèse dans le muscle squelettique et le coeur humains. L'invention concerne dans un autre aspect l'utilisation de ces gènes pour corriger des dysfonctionnements de thermogenèse dans le muscle squelettique et le coeur humains. La présente invention permet d'exploiter de nouvelles méthodes thérapeutiques (ou préventives) destinées à des troubles tels que l'obésité ou la cachexie. Suite à l'identification et à l'isolement des gènes codant UCP3¿L? et UCP3¿S?, il est en effet possible de développer des médicaments qui agissent sur la base d'une correction de manque ou d'excès d'UCP3, par thérapie génique ou grâce à des oligonucléotides antisens liés à la séquence du gène en question ou à un de ses fragments.

Affiliated with

Also associated with

Rating

Uncoupling protein homologue: ucp 3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Uncoupling protein homologue: ucp 3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uncoupling protein homologue: ucp 3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1358453