Undercarboxylated/uncarboxylated osteocalcin increases...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61P 3/00 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2663069

The present invention relates to methods and compositions for treating and diagnosing disorders related to energy metabolism and the OST-PTP signaling pathway involving gamma-carboxylase, osteocalcin and adiponectin. Such disorders include, but are not limited to, metabolic syndrome, glucose intolerance, diabetes types 1 and 2, atherosclerosis and obesity.

La présente invention concerne des méthodes et des compositions de traitement et de diagnostic des troubles associés au métabolisme énergétique et à la voie de signalisation OST-PTP impliquant la gamma-carboxylase, l'ostéocalcine et l'adiponectine. Lesdits troubles comprennent, entre autres, le syndrome métabolique, l'intolérance au glucose, le diabète de type 1 et de type 2, l'athérosclérose et l'obésité.

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