Unexpected surface proteins in neisseria meningitidis

Details Unexpected surface proteins in neisseria meningitidis Unexpected surface proteins in neisseria meningitidis

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01)

Patent

CA 2506318

217 proteins have, contrary to expectations, been found in the membrane of Neisseria meningitidis. Of these 217, 76 in particular evaded all algorithmic methods for predicting membrane localisation. Existing knowledge of protein trafficking pathways in meningococcus does not explain how or why these proteins are located in the bacterial membrane e.g. there is no apparent biochemical reason for a DNA helicase or a chromosomal replication initiator protein to be found in the membrane. These 217 proteins are provided as membrane proteins.

Contre toute attente, 217 protéines ont été trouvées dans la membrane de Neisseria meningitidis. Sur ces 217 protéines, 76 en particulier échappaient à toute méthode algorithmique de prédiction de localisation sur la membrane. Les connaissances existantes sur les canaux de trafic protéique chez le méningocoque n'expliquent pas comment ou pourquoi ces protéines sont situées dans la membrane bactérienne. En d'autres termes, il n'existe aucune raison biochimique apparente de trouver dans la membrane une ADN hélicase ou une protéine d'initiation de la réplication chromosomique. Ces 217 protéines sont décrites comme protéines membranaires.

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