Ungulates with genetically modified immune systems

Details Ungulates with genetically modified immune systems Ungulates with genetically modified immune systems

A - Human Necessities

01

K

A01K 67/027 (2006.01)

Patent

CA 2585098

The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.

L'invention porte sur des animaux ongulés, des tissus et des organes ainsi que sur des cellules et des lignes cellulaires issues de ces animaux, de ces tissus et de ces organes, qui ne peuvent exprimer des loci d'immunoglobines endogènes fonctionnelles. L'invention concerne aussi des animaux ongulés, des tissus et des organes ainsi que des lignes et des lignes cellulaires issues de ces animaux, tissus et organes qui expriment des loci d'immunoglobines xenogènes, tels que des loci d'immunoglobines humaines. L'invention se rapporte aussi à des ongulés, tels qu'une séquence d'ADN génomique porcin d'immunoglobines de chaînes lourdes et légères. Ces animaux, tissus et organes peuvent être utilisés dans la recherche et la thérapie médicale. De plus, l'invention porte sur des procédés de préparation de ces animaux, organes, tissus et cellules.

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