Unigene unidirectional antisense library

Details Unigene unidirectional antisense library Unigene unidirectional antisense library

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2460603

The present invention provides a high throughput system for functional genomics using a unigene antisense library comprising LC-antisense compounds. The antisense compounds were specific and effective for the elimination of target mRNA. Thus, the system of the present invention is used as temporary knock-down system to unveil functions of genes critical for diseases. The system of the present invention can be adopted not only for functional genomics but also for effectively validating target for antisense or other molecular therapeutics against various malignancies, infections, and other diseases by blocking specific genes involved in the disease.

L'invention concerne un système à rendement élevé destiné à une génomique fonctionnelle mettant en oeuvre une banque anti-sens monogène comprenant des composés LC-anti-sens. Ces composés sont spécifiques et efficaces pour l'élimination d'un ARNm cible. Par conséquent, le système selon l'invention est utilisé comme système d'affaiblissement permettant de dévoiler des fonctions de gènes critiques pour certaines maladies. Le système selon l'invention peut être adopté non seulement pour la génomique fonctionnelle mais également pour la validation efficace d'agents thérapeutiques anti-sens ou moléculaires agissant contre diverses malignités, infections et d'autres maladies par blocage de gènes spécifiques impliqués dans la maladie.

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