C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/245 (2006.01) A61K 39/42 (2006.01) C07H 21/00 (2006.01) C07K 14/03 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12N 9/96 (2006.01) C12N 15/11 (2006.01) C12N 15/38 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2244373
This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) polypeptides. This invention provides an isolated polypeptide molecule of KSHV. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's Sarcoma in a cell.
L'invention concerne une molécule isolée d'acide nucléique qui code pour des polypeptides de l'herpèsvirus associé au sarcome de Kaposi, une molécule polypeptidique isolée de ce virus, un anticorps spécifique de ce polypeptide, des molécules oligonucléotidiques antisense et à triple brin, un vaccin contre le sarcome de Kaposi, ainsi que des méthodes de vaccination, de prophylaxie, de diagnostic et de traitement d'un sujet atteint du sarcome de Kaposi et de détection dans une cellule de l'expression d'un ADN viral associé au sarcome de Kaposi.
Bohenzky Roy A.
Chang Yuan
Edelman Isidore S.
Moore Patrick S.
Russo James J.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
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