A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/4164 (2006.01) A61K 31/435 (2006.01) A61K 31/4409 (2006.01) A61K 31/4412 (2006.01) A61K 31/535 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2671502
Unit doses of factor Xa inhibitor compounds and methods of using these compounds for inhibiting blood coagulation in a human patient are taught herein. The unit dose of the factor Xa inhibitor compounds disclosed herein required to inhibit coagulation in a primate is lower than the unit dose required to obtain similar levels of coagulation inhibition in other animal models, such as rodents. Also taught are in vitro assays useful in predicting in vivo antithrombotic activity in humans.
L'invention concerne des doses unitaires de composés inhibiteurs du facteur Xa et des procédés utilisant ces composés pour inhiber la coagulation du sang chez un patient humain. La dose unitaire de composés inhibiteurs du facteur Xa décrite dans le présent document nécessaire pour inhiber la coagulation chez un primate est plus faible que la dose unitaire requise pour obtenir des niveaux similaires d'inhibition de la coagulation chez d'autres modèles d'animaux, tels que les rongeurs. L'invention concerne également des essais in vitro utiles pour prédire l'activité anti-thrombotique in vivo chez les humains.
Abe Keith
Hollenbach Stanley J.
Sinha Uma
Millennium Pharmaceuticals Inc.
Torys Llp
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