Universal carrier for targeting molecules to gb3 receptor...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 39/385 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/25 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2435712

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

La présente invention concerne un support polypeptidique universel pour cibler directement ou indirectement une molécule pour les cellules d'expression du récepteur de Gb3 et présentant la formule STxB-Z(n)-Cys . Dans cette dernière STxB est la sous-unité B de la Toxine de Shiga ou un équivalent fonctionnel. Z est un acide aminé dépourvu du groupe sulfydryle, n étant égal à 0, 1, ou un polypeptide. Cys est la Cystéine d'acide aminé. L'invention concerne aussi l'utilisation de ces composés pour la présentation des antigènes par les molécules du complexe majeur d'histocompatilibé (MHC) de classe I et de classe II.

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